Liga Balm:
A Pain-Relieving Ointment
Liga Balm is the first and only product on the market specifically formulated not only to relieve pain but also to reduce inflammation and support the healing process at the site of application. This is due to its unique inclusion of natural cod liver oil combined with other counterirritants. Cod liver oil is well-recognized for its therapeutic properties and serves as a rich source of Vitamin A, Vitamin D, Omega-3 fatty acids (EPA and DHA) and other healthy fats.
Thus, Liga Balm = Reduced Inflammation + Promote Healing → Total Pain Relief Liga Balm - Trademark pending and Patent pending with USPTO
What Causes Pain?
Pain is a complex condition that can be challenging to manage. Although there are several treatments available - such
as topical NSAIDs (non-steroidal anti-inflammatory drugs), acetaminophen, oral NSAIDs, opioids, and complementary medicine - many people still experience insufficient pain relief. Chronic pain often begins with an episode of acute pain following injury, surgery, or illness. Normally, this pain resolves as the body heals, but sometimes it persists long after recovery, lasting for years or even a lifetime. The mechanisms behind chronic pain are not yet fully understood. Research suggests that chronic pain may result from ongoing inflammation at the site of injury, potentially caused by an autoimmune response involving nerve damage or tissue injury. This persistent inflammation is linked to the continuation of pain. For chronic pain management to be truly effective, topical analgesics should help repair damaged nerves or tissues, thereby reducing inflammation and supporting healing at the affected site. Achieving this is critical for relieving pain. However, current medications, including both opioid and non-opioid drugs, oral and topical formulations, whether over-the-counter or prescription, do not actually target the underlying causes, which are often tissue or nerve damage.
References:
1. Yang J, Bauer BA, Wahner Roedler DL, Chon TY, Xiao L. The Modified WHO Analgesic Ladder: Is it appropriate for Chronic Non-cancer Pain? Pain Res 2020; 13: 411-417
2. Wiffen PJ, Xia J. Systemic Review of Topical Diclofenac for the Treatment of Acute and Chronic Musculoskeletal Pain. Curr Med ResOpin 2020; 36(4): 637-650Altman R, Bosch B, Brune K, Patrignani Paola, Young C. Advances in NSAID Development: Evolution of Diclofenac Products UsingPharmaceutical Technology. Drug 2015; 75(8): 859-877
3. Derry S, Moore RA, Rabbie R. Topical NSAIDs for Chronc Musculoskeletal Pain in Adult. Cochrane Database Syst Rev 2012 Sep 12;9(9)Banning M. Topical Diclofenac: Clinical Effectiveness and Current Uses in Osteoarthritis of the Knee and Soft tissue Injuries. ExpertOpin Pharmacother 2008; 9(16): 2921-2929
4. Derry S, Conaghan P, Da Silva JA, Wiffen PJ, Moore RA. Topical NSAIDs for Chronic Musculoskeletal Pain in Adults. CochraneDatabase Rev 2016 Apr 22;
5. Altman R, Barkin RL. Topical Therapy for Osteoarthritis: Clinical and Pharmacologic Perspective. Postgrad Med 2009; 121(2): 139-147
The Background
Topical pain-relieving preparations - including topical analgesics, antipruritic, and anesthetic agents are frequently utilized to manage pain by modulating sensory receptors within the skin. These agents primarily function by depressing cutaneous sensory receptors responsible for transmitting pain signals, thereby providing targeted, localized relief. Distinct from analgesics and anesthetics, topical counterirritants, when applied within specific concentration ranges to intact skin, exert their effects by stimulating cutaneous receptors. This stimulation elicits a sensation of warmth at the application site, which indirectly mitigates pain through distraction from the original discomfort.
In recent years, topical nonsteroidal anti-inflammatory drugs (NSAIDs), available as gels or patches or solution, have gained widespread use. These preparations may reduce inflammation locally at the site of application, offering effective pain relief for various musculoskeletal disorders. However, due to potential adverse effects resulting from dermal absorption, their use is generally restricted to joint-related pain, and they are not recommended for managing pain in the hips, neck, back, or shoulders. Overall, all the topical analgesic formulations serve as valuable adjuncts to oral medications, enhancing the comprehensive management of musculoskeletal pain. Their localized mechanism not only alleviates pain but also augments the efficacy of systemic pain management strategies.
The extensive reliance on opioids and & "pain cocktails" for chronic musculoskeletal conditions, combined with the substantial risks linked to NSAIDs use, has raised significant safety concerns. This situation has contributed to the ongoing opioid crisis in the United States, underscoring an urgent need for safer, non-invasive, and more effective pain management options. Liga Balm is an advanced external analgesic ointment created to reduce inflammation where it’s applied, speed up healing, and ultimately deliver reliable pain relief. Developed with insights from both biological and in pharmaceutical sciences, Liga Balm’s ingredients are carefully chosen and combined in a new and innovative way. This unique strategy sets Liga Balm apart from other external pain relief products on the market, highlighting its pioneering role and effectiveness in managing pain.
References:
1. Hunkar T, Aktan F, Ceylan A, Karasu C. Effect if Cod Liver Oil on Tissue Antioxidant Pathways in Normal and Streptozotocin-DiabeticRats. Cell Biochem Funct 2002; 20(4): 297-302
2. Rio E, Moseley L, Purdam C, Samiric T, Kidgell D, Pearce AJ, Jaberzadeh S, Cook J. The Pain of Tendinopathy: Physiological orPathophysiological? Sport Med 2014; 44(1): 9-23
3. Dery S, Wiffen PJ, Kalso EA, Bell RF, Aldington D, Phillips T, Gaskell H, Moore RA. Topical Analgesic for Acute and Chronic Pain inAdult – An Overview of Cochrane Reviews. Cochrane Database Syst Rev 2017 May 12; 5(5)
4. Kocot-Kepska M, Zajaczkowska R, Mika J, Kopsky DJ, Wordliczek J, Dobrogowski J, Przeklasa-Muszynska A. Topical Treatments andTheir Molecular/Cellular Mechanism in Patients with Peripheral Neuropathic Pain-Narrative Review. Pharmaceutics 2021; 13(4): 450-457
5. Mifflin KA, Kerr BJ. The transition from acute to chronic pain: understanding how different biological systems interact. Can J Anaesth.2014; 61(2):112-122.