OUR INNOVATIVE APPROACH

Within the human body, omega-6 and omega-3 fatty acid metabolic pathways give rise to critical bioactive
lipids. Linoleic acid (LA, n-6) and alpha-linolenic acid (ALA, n-3) serve as precursors for arachidonic acid (ARA,
n-6), eicosapentaenoic acid (EPA, n-3), and docosahexaenoic acid (DHA, n-3). These metabolites play
essential roles in maintaining homeostasis and modulating inflammation. ARA predominantly generates pro-
inflammatory eicosanoids, while EPA and DHA produce anti-inflammatory eicosanoids, including
prostaglandins that selectively inhibit local inflammation. The application of  Liga Balm is formulated to enhance
local concentrations of prostaglandin 3 (PGI3) and thromboxane 3 (TXA3), both derived from EPA, thereby
inducing vasodilation and creating an antithrombotic environment at sites of tissue damage. This leads to
increased concentrations of growth factors, cytokines, immunoglobulins, and oxygen, ultimately accelerating
the healing process. Furthermore, EPA and DHA facilitate the production of specialized pro-resolving
mediators - resolvins, protectins, and maresins which are instrumental in resolving inflammation, promoting
tissue regeneration, enhancing tissue repair, and alleviating pain. Unlike systemic hormones, eicosanoids are synthesized and act within cells, regulating processes such as calcium transport, vascular tone, coagulation, cellular secretion, and proliferation.

EPA and DHA also modulate inflammation through several cellular mechanisms, including altering the fatty
acid composition of cell membrane phospholipids and disrupting lipid raft domains. Additionally, they activate
the anti-inflammatory transcription factor peroxisome proliferator-activated receptor γ (PPARγ), thereby
supporting anti-inflammatory gene expression.

The multi-faceted mechanism of action of cod liver oil and additional components in  Liga Balm is fundamental
to reducing swelling and inflammation, preventing subsequent injury, and supporting efficient tissue repair. The
intended clinical outcome of Liga Balm is sustained and optimal anti-inflammatory activity, accelerated healing process, and provides effective pain relief, which collectively contribute to minimizing the recurrence of pain.